The primary hurdle after contract ratification between buyer and seller is the home inspection, but even after repairs are agreed on, that doesn't mean that you should completely bank on a closing, whether you're a buyer or a seller. The below aren't far-fetched. In fact, below in red are some examples I've seen in transactions where I've personally represented buyer or seller where a contract either got derailed or that could have derailed a contract that weren't predicated on the home inspection. In black I'll list some other possibilities. I'll start with a doozy that happened the week of closing after the sellers had moved out the weekend before:
Buyer Fraud Discovered Week of Closing After Sellers Unstage the Home
Major Foundation Work Uncovered Due to Fraudulent Prior Contractor
Appraisal Issues
Title Issues
Financing Issues
Survey Issues
Non-Disclosed Material Adverse Facts Discovered After Closing
Seller Didn't Perform Work as Agreed
Insurance Issues
Condo/Home Owner's Association
System in Home Breaks & Requires Replacement After Home Inspection
Agent Misunderstands Contract
Other Contingencies
Destruction of Home on Home I Showed
Change in Status of Buyer or Seller
Disagreement Among 1 Side
Buyer or Seller Gets Cold Feet
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